A thin domain layer for postmortem forensic toxicology, aimed at the hard
case where peripheral blood is compromised (hemodilution after water
submersion, or decompositional change) and the analyst must reason from
alternative matrices (liver, vitreous humour, brain, gastric contents).
Like taphonomy, it adds no new statistics: it supplies typed,
zero-row schemas and dispatches quantitation to base-R least squares and the
antemortem-vs-artefact question to MORIE's existing likelihood-ratio
machinery (morie_taphonomy_likelihood_ratio).
Details
This module ships no data. Calibrator responses, case measurements,
and matrix concentrations must be supplied by the caller from real analytical
runs. morie_tox_matrix_schema returns a typed zero-row frame;
it never fabricates rows.
What it can and cannot do. It fits an internal-standard calibration curve and inverse-predicts an unknown concentration with LOD/LOQ, flags postmortem redistribution from a central:peripheral ratio, and quantifies support for antemortem ingestion versus postmortem microbial production as a likelihood ratio. It reports bounded statistical support, never proof or a posterior probability, and it does not establish cause of death.
References
Dinis-Oliveira RJ, et al. (2010). Collection of biological samples in forensic toxicology. Toxicology Mechanisms and Methods 20(7), 363–414. doi:10.3109/15376516.2010.497976
Pounder DJ, Jones GR (1990). Post-mortem drug redistribution – a toxicological nightmare. Forensic Science International 45(3), 253–263. doi:10.1016/0379-0738(90)90182-X
Kugelberg FC, Jones AW (2007). Interpreting results of ethanol analysis in postmortem specimens. Forensic Science International 165(1), 10–29. doi:10.1016/j.forsciint.2006.05.004