Skip to contents

Flag postmortem redistribution from a central:peripheral concentration ratio

Source: R/tox.R
morie_tox_pmr_ratio.Rd

Postmortem redistribution (PMR) inflates central-blood (e.g. cardiac) drug concentrations relative to peripheral (femoral) blood after death, so a raw central value can overstate the antemortem level. The central:peripheral (C/P) ratio is the standard screen: C/P near 1 is stable; larger ratios indicate redistribution and unreliable central quantitation.

Usage

morie_tox_pmr_ratio(central, peripheral)

Arguments

central

Central (cardiac) blood concentration (> 0).

peripheral

Peripheral (femoral) blood concentration (> 0).

Value

A list with the cp_ratio and an ordinal redistribution flag ("minimal", "modest", or "significant") plus an interpretation string. Thresholds follow the common C/P > 1 (modest) and C/P > 2–3 (significant) forensic convention.

Examples

morie_tox_pmr_ratio(central = 2.4, peripheral = 0.8)
#> $cp_ratio
#> [1] 3
#> 
#> $redistribution
#> [1] "significant"
#> 
#> $interpretation
#> [1] "C/P ratio = 3.00 (significant redistribution). Marked redistribution; the central value likely overstates the antemortem concentration -- interpret from peripheral blood or an alternative matrix."
#>