Concentration-response functions for PM2.5 and NO2

morie_envhealth_crf_pm25() is log-linear for all-cause mortality with the pooled cohort estimate of the WHO 2021 guideline review (Chen and Hoek 2020: RR 1.08, 95\ $$RR(z) = \exp(\ln(1.08) (z - z_{cf}) / 10)$$ for \(z > z_{cf}\) and 1 otherwise; for the cause-specific outcomes (IHD, stroke) it is the Integrated Exposure-Response curve of Burnett et al. (2014, Eq. 1), $$RR(z) = 1 + \alpha (1 - e^{-\gamma (z - z_{cf})^{\delta}}),$$ with the GBD 2013 triples; the IER was fit per cause and has no all-cause form. morie_envhealth_crf_no2() is the log-linear function of the WHO 2021 review (Huangfu and Atkinson 2020: RR 1.02, 95\ 10 micrograms per cubic metre for all-cause mortality), $$RR(z) = \exp(\beta (z - z_{cf}) / 10).$$

Usage

morie_envhealth_crf_pm25(
  exposure,
  outcome = "all_cause_mortality",
  reference_conc = 5.8
)

morie_envhealth_crf_no2(
  exposure,
  outcome = "all_cause_mortality",
  reference_conc = 10,
  beta_per_10 = NULL
)

morie_envhealth_cheatsheet()

Arguments

exposure

Ambient concentration in micrograms per cubic metre (scalar or vector).

outcome

PM2.5: "all_cause_mortality", "ihd" or "stroke". NO2: "all_cause_mortality", "respiratory" or "childhood_asthma".

reference_conc

Counterfactual concentration below which no excess risk is assumed (PM2.5 default 5.8, NO2 default 10).

beta_per_10

Optional log-RR per 10 units overriding the NO2 outcome table.

Value

A list of class morie_envhealth_crf with rr, log_rr, reference_conc, exposure_conc, pollutant, citation and extra.

References

Chen, J. and Hoek, G. (2020). Environment International, 143, 105974. Huangfu, P. and Atkinson, R. (2020). Environment International, 144, 105998. Burnett, R. T. et al. (2014). Environmental Health Perspectives, 122(4), 397-403. WHO (2021). Global Air Quality Guidelines.

Examples

morie_envhealth_crf_pm25(12)$rr
#> [1] 1.048873
morie_envhealth_crf_no2(25, outcome = "respiratory")$rr
#> [1] 1.04446